C4d Glomerular Deposits and Disease Progression in Native Idiopathic Membranous Nephropathy

نویسندگان

  • Vincenzo Sepe
  • Antonio Dal Canton
چکیده

Volume 5 • Issue 5 • 1000212 J Nephrol Ther ISSN: 2161-0959 JNT, an open access journal C4d Glomerular Deposits and Disease Progression in Native Idiopathic Membranous Nephropathy Vincenzo Sepe1*, Paolo Albrizio2, and Antonio Dal Canton1,2 1Unit of Nephrology, Dialysis, Transplantation, Fondazione I.R.C.C.S., Policlinico San Matteo, Italy 2Chair of Nephrology, University of Pavia, Viale Camillo Golgi, Italy

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Clinicopathologic features and outcome of membranous nephropathy in Markaz Tebi children hospital

Background and Objectives: This research study was conducted to determine the correlation between the clinicopathologic features and the outcome of membranous nephropathy. Materials and Methods: Data were retrospectively reviewed from all patients with a diagnosis of membranous nephropathy. Demographic, ...

متن کامل

Recurrent membranous nephropathy in an allograft caused by IgG3κ targeting the PLA2 receptor.

Up to 80% of patients with idiopathic membranous nephropathy have non-complement-fixing IgG4 autoantibodies to the phospholipase A2 receptor (PLA2R). Membranous nephropathy recurs in approximately 40% of patients after kidney transplantation, but the mechanism is unknown. Here, we describe a patient with recurrent membranous nephropathy 13 days after kidney transplantation whose graft biopsy sp...

متن کامل

Role of Anti-Phospholipase A(2) Receptor Antibodies in the Differential Diagnosis of Diabetic and Membranous Nephropathy

D iabetic nephropathy and membranous nephropathy can both present with nephrotic syndrome. Here, we report on a 43-year-old female patient suffering from type 1 diabetes, diabetic retinopathy, arterial hypertension, and nephrotic syndrome. Blood glucose levels were poorly controlled by a basal-bolus insulin regimen as shown by an HbA1c of 15.9% (150 mmol/mol). The concomitant antihypertensive m...

متن کامل

Pathogenesis and significance of glomerular C4d deposition in lupus nephritis: activation of classical and lectin pathways.

Immune complex-mediated complement activation through the classic pathway plays a key role in the pathogenesis of lupus nephritis (LN). C4d deposition in renal tissue reflects the prognosis of systemic lupus erythematosus (SLE). The aim of the current study is to investigate the pathogenesis and clinicopathologic significance of glomerular C4d deposition in LN. We retrospectively analyzed clini...

متن کامل

Clinicopathological features of idiopathic membranous nephropathy combined with IgA nephropathy: a retrospective analysis of 9 cases

BACKGROUND The concomitant presence of idiopathic membranous nephropathy and IgA nephropathy is rare. Here, we report 9 cases of phospholipase-A2-receptor (PLA2R) positive idiopathic membranous nephritis combined with IgA nephropathy, while reviewing publications regarding the pathological characteristics of this glomerolonephritis complication. CASE PRESENTATION Nine cases of renal biopsy ti...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015